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- Title:
Radical fluoroarylation in radiochemical synthesis
- Document type:
- Article
- Author(s):
- Hultsch, C; Blank, O; Wester, HJ; Heinrich, MR
- Abstract:
- In this study, we report on the radical [F-18]fluoroarylation of different olefins using 4-[F-18]fluorobenzenediazonium ions to provide a new route to radiopharmaceuticals containing a deactivated, 4-[F-18]fluoro substituted phenyl group. This new methodology was shown to be well suited for the synthesis of F-18-labelled stilbenes. Stilbene 7 is now accessible within 80 min in 30-45% overall radiochemical yield starting from [F-18]fluoride. (C) 2008 Elsevier Ltd. All rights reserved.
- Journal title abbreviation:
- Tetrahedron Lett
- Year:
- 2008
- Journal volume:
- 49
- Journal issue:
- 11
- Pages contribution:
- 1881-1883
- Language:
- eng
- Print-ISSN:
- 0040-4039
- TUM Institution:
- Klinik und Poliklinik für Nuklearmedizin
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