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Title:

Radical fluoroarylation in radiochemical synthesis

Document type:
Article
Author(s):
Hultsch, C; Blank, O; Wester, HJ; Heinrich, MR
Abstract:
In this study, we report on the radical [F-18]fluoroarylation of different olefins using 4-[F-18]fluorobenzenediazonium ions to provide a new route to radiopharmaceuticals containing a deactivated, 4-[F-18]fluoro substituted phenyl group. This new methodology was shown to be well suited for the synthesis of F-18-labelled stilbenes. Stilbene 7 is now accessible within 80 min in 30-45% overall radiochemical yield starting from [F-18]fluoride. (C) 2008 Elsevier Ltd. All rights reserved.
Journal title abbreviation:
Tetrahedron Lett
Year:
2008
Journal volume:
49
Journal issue:
11
Pages contribution:
1881-1883
Language:
eng
Print-ISSN:
0040-4039
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
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