The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells.

Titel:: The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells.
Dokumenttyp:: Journal Article; Review
Autor(en):: Gehrmann, M; Radons, J; Molls, M; Multhoff, G
Abstract:: Evidence that membrane-bound and extracellular heat shock proteins (HSPs) with molecular weights of 70 and 90 kDa are potent stimulators of the immune responses has accumulated over the last decade. In this review, we discuss the modulation of Hsp70 expression, a major stress-inducible member of the HSP70 family, in the cytoplasm and on the plasma membrane of tumor cells by clinically applied interventions such as radio- and chemotherapy.
Zeitschriftentitel:: Cell Stress Chaperones
Jahr:: 2008
Band / Volume:: 13
Heft / Issue:: 1
Seitenangaben Beitrag:: 1-10
Sprache:: eng
Volltext / DOI:: doi:10.1007/s12192-007-0006-0
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/18347936
Print-ISSN:: 1355-8145
TUM Einrichtung:: Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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