We examined the influence of positive surgical margins (R1) on several pathological and clinical parameters in prostate cancer with pathological stage T2 or T3 on progression free survival. Patients with a pT2R1-tumor had no higher risk for PSA-progression than patients with pT2R0. Patients with pT2R1 exhibited higher median PSA at diagnosis, and a higher proportion of tumors with poor differentiation than patients with pT2R0. Progression free survival was in the pT2R0 and pT2R1 groups significantly higher than in patients with a pT3-tumor. Based on these results prostate cancer specimen with positive surgical margins and no extracapular extension should probably neither be classified as T2 nor as T3 disease.
«We examined the influence of positive surgical margins (R1) on several pathological and clinical parameters in prostate cancer with pathological stage T2 or T3 on progression free survival. Patients with a pT2R1-tumor had no higher risk for PSA-progression than patients with pT2R0. Patients with pT2R1 exhibited higher median PSA at diagnosis, and a higher proportion of tumors with poor differentiation than patients with pT2R0. Progression free survival was in the pT2R0 and pT2R1 groups significa...
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