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Title:

Metabolic profiling reveals distinct variations linked to nicotine consumption in humans--first results from the KORA study.

Document type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Wang-Sattler, R; Yu, Y; Mittelstrass, K; Lattka, E; Altmaier, E; Gieger, C; Ladwig, KH; Dahmen, N; Weinberger, KM; Hao, P; Liu, L; Li, Y; Wichmann, HE; Adamski, J; Suhre, K; Illig, T
Abstract:
Exposure to nicotine during smoking causes a multitude of metabolic changes that are poorly understood. We quantified and analyzed 198 metabolites in 283 serum samples from the human cohort KORA (Cooperative Health Research in the Region of Augsburg). Multivariate analysis of metabolic profiles revealed that the group of smokers could be clearly differentiated from the groups of former smokers and non-smokers. Moreover, 23 lipid metabolites were identified as nicotine-dependent biomarkers. The l...     »
Journal title abbreviation:
PLoS ONE
Year:
2008
Journal volume:
3
Journal issue:
12
Pages contribution:
e3863
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0003863
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19057651
Print-ISSN:
1932-6203
TUM Institution:
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
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