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Titel:

Pretreatment 18F-FAZA PET predicts success of hypoxia-directed radiochemotherapy using tirapazamine.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Beck, R; Röper, B; Carlsen, JM; Huisman, MC; Lebschi, JA; Andratschke, N; Picchio, M; Souvatzoglou, M; Machulla, HJ; Piert, M
Abstract:
We evaluated the predictive value of PET using the hypoxia tracer (18)F-fluoroazomycin arabinoside ((18)F-FAZA) for success of radiotherapy in combination with tirapazamine, a specific cytotoxin for hypoxic cells. METHODS: Imaging was performed on EMT6 tumor-bearing nude mice before allocating mice into 4 groups: radiochemotherapy (RCT: 8 fractions of 4.5 Gy within 4 d combined with tirapazamine, 14 mg/kg), radiotherapy alone (RT), chemotherapy alone (tirapazamine) (CHT), or control. Treatment s...     »
Zeitschriftentitel:
J Nucl Med
Jahr:
2007
Band / Volume:
48
Heft / Issue:
6
Seitenangaben Beitrag:
973-80
Sprache:
eng
Volltext / DOI:
doi:10.2967/jnumed.106.038570
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17536108
Print-ISSN:
0161-5505
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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