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Titel:

Detrimental effects of an antibody directed against tumor necrosis factor alpha in experimental kidney irradiation.

Dokumenttyp:
Journal Article; Article
Autor(en):
Nieder, C; Schnaiter, A; Weber, WA; Schill, S; Andratschke, N; Schwaiger, M; Molls, M
Abstract:
Antibodies directed against tumor necrosis factor (TNF)-alpha are clinically used for Crohn's disease, rheumatoid arthritis and psoriasis. TNF-alpha is also an important cytokine in radiotherapy because it mediates inflammatory responses in normal tissues. To study the influence of TNF-alpha inhibition on radiation toxicity, we used a well-established mouse model of kidney irradiation, where the portal also includes parts of the intestine. Mice were treated with single-fraction radiotherapy to t...     »
Zeitschriftentitel:
Anticancer Res
Jahr:
2007
Band / Volume:
27
Heft / Issue:
4B
Seitenangaben Beitrag:
2353-7
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17695525
Print-ISSN:
0250-7005
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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