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Titel:

Non-fluent progressive aphasia: cerebral metabolic patterns and brain reserve.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Perneczky, R; Diehl-Schmid, J; Pohl, C; Drzezga, A; Kurz, A
Abstract:
Functional imaging studies suggest that brain reserve allows patients with Alzheimer's disease with more years of schooling to cope better with brain damage. No studies exist on patients with non-fluent progressive aphasia (NFPA). We aimed to explore metabolic patterns of patients with NFPA and to provide evidence for brain reserve in NFPA. 11 right-handed patients with NFPA and 16 age-matched controls underwent (18)F-FDG PET imaging. Scans of patients and controls were compared in SPM2. A linear regression analysis with glucose metabolism as dependent variable and years of schooling as the independent variable, adjusted for age, gender, and a total score of the CERAD neuropsychological battery was conducted. The NFPA group showed a hypometabolism of the left hemisphere including the middle frontal, and inferior temporal and angular gyri, and the bilateral caudate nuclei and thalami (p(corr)<0.05). The regression analysis revealed a significant inverse association between education and glucose metabolism in the left inferior temporal, parahippocampal, and supramarginal gyri (p(corr)<0.05). We conclude that brain reserve is also present in NFPA.
Zeitschriftentitel:
Brain Res
Jahr:
2007
Band / Volume:
1133
Heft / Issue:
1
Seitenangaben Beitrag:
178-85
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.brainres.2006.11.054
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17184752
Print-ISSN:
0006-8993
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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