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Titel:

Differential opioid action on sensory and affective cerebral pain processing.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Oertel, BG; Preibisch, C; Wallenhorst, T; Hummel, T; Geisslinger, G; Lanfermann, H; Lotsch, J
Abstract:
Low doses of morphine, the most commonly used opioid analgesic, have been shown to significantly reduce the affective but not the sensory intensive dimension of pain. This suggests differential dose-response relationships of opioid analgesia on the sensory and affective components of pain. We investigated the effects of different alfentanil plasma concentration levels (0, 19.6+/-2.7, 47.2+/-7.6, and 76.6+/-11.3 ng/ml) on pain-related brain activation achieved by short pulses of gaseous CO(2) del...     »
Zeitschriftentitel:
Clin Pharmacol Ther
Jahr:
2008
Band / Volume:
83
Heft / Issue:
4
Seitenangaben Beitrag:
577-88
Sprache:
eng
Volltext / DOI:
doi:10.1038/sj.clpt.6100441
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18030306
Print-ISSN:
0009-9236
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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