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Title:

Differential opioid action on sensory and affective cerebral pain processing.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Oertel, BG; Preibisch, C; Wallenhorst, T; Hummel, T; Geisslinger, G; Lanfermann, H; Lotsch, J
Abstract:
Low doses of morphine, the most commonly used opioid analgesic, have been shown to significantly reduce the affective but not the sensory intensive dimension of pain. This suggests differential dose-response relationships of opioid analgesia on the sensory and affective components of pain. We investigated the effects of different alfentanil plasma concentration levels (0, 19.6+/-2.7, 47.2+/-7.6, and 76.6+/-11.3 ng/ml) on pain-related brain activation achieved by short pulses of gaseous CO(2) del...     »
Journal title abbreviation:
Clin Pharmacol Ther
Year:
2008
Journal volume:
83
Journal issue:
4
Pages contribution:
577-88
Language:
eng
Fulltext / DOI:
doi:10.1038/sj.clpt.6100441
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18030306
Print-ISSN:
0009-9236
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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