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Title:

Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Chen, JW; Breckwoldt, MO; Aikawa, E; Chiang, G; Weissleder, R
Abstract:
Inflammatory demyelinating plaques are the pathologic hallmark of active multiple sclerosis and often precede clinical manifestations. Non-invasive early detection of active plaques would thus be crucial in establishing pre-symptomatic diagnosis and could lead to early preventive treatment strategies. Using murine experimental autoimmune encephalomyelitis as a model of multiple sclerosis, we demonstrate that a prototype paramagnetic myeloperoxidase (MPO) sensor can detect and confirm more, small...     »
Journal title abbreviation:
Brain
Year:
2008
Journal volume:
131
Journal issue:
Pt 4
Pages contribution:
1123-33
Language:
eng
Fulltext / DOI:
doi:10.1093/brain/awn004
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18234693
Print-ISSN:
0006-8950
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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