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Titel:

Novel biosensor-based analytic device for the detection of anti-double-stranded DNA antibodies.

Dokumenttyp:
Journal Article
Autor(en):
Buhl, A; Metzger, JH; Heegaard, NH; von Landenberg, P; Fleck, M; Luppa, PB
Abstract:
BACKGROUND: Patients with systemic lupus erythematosus (SLE) develop a wide variety of serologic manifestations, including double-stranded DNA autoantibodies (anti-dsDNA). The determination of the potentially pathogenic autoantibodies is diagnostically relevant. METHODS: We developed a novel surface plasmon resonance (SPR) biosensor chip for studies of dsDNA and anti-dsDNA binding. A synthetic oligonucleotide was coupled to biotinylated human transferrin, hybridized with the complementary antist...     »
Zeitschriftentitel:
Clin Chem
Jahr:
2007
Band / Volume:
53
Heft / Issue:
2
Seitenangaben Beitrag:
334-41
Sprache:
eng
Volltext / DOI:
doi:10.1373/clinchem.2006.077339
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17185362
Print-ISSN:
0009-9147
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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