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Title:

Translating mucosal antigen based prevention of autoimmune diabetes to human.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Bonifacio, E; Ziegler, A; Achenbach, P; Barker, J; Eisenbarth, G
Abstract:
Mucosal administration of autoantigen (insulin) to animal models has been demonstrated to be effective in preventing autoimmune diabetes. Efficacy is dependent upon the dose and the age at which it is delivered. Because of its low toxicity, mucosal administration of insulin represents an attractive preventive therapy in human. Translation of what is efficacious in animal models is, however, challenging. We have proposed mucosal insulin vaccination as a primary prevention strategy in children on...     »
Journal title abbreviation:
Novartis Found Symp
Year:
2008
Journal volume:
292
Pages contribution:
187-99; discussion 199-20
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19203100
Print-ISSN:
1528-2511
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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