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Titel:

Translating mucosal antigen based prevention of autoimmune diabetes to human.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Bonifacio, E; Ziegler, A; Achenbach, P; Barker, J; Eisenbarth, G
Abstract:
Mucosal administration of autoantigen (insulin) to animal models has been demonstrated to be effective in preventing autoimmune diabetes. Efficacy is dependent upon the dose and the age at which it is delivered. Because of its low toxicity, mucosal administration of insulin represents an attractive preventive therapy in human. Translation of what is efficacious in animal models is, however, challenging. We have proposed mucosal insulin vaccination as a primary prevention strategy in children on...     »
Zeitschriftentitel:
Novartis Found Symp
Jahr:
2008
Band / Volume:
292
Seitenangaben Beitrag:
187-99; discussion 199-20
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19203100
Print-ISSN:
1528-2511
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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