User: Guest  Login
Title:

SLC30A8 (ZnT8) Polymorphism is Associated with Young Age at Type 1 Diabetes Onset.

Document type:
Journal Article; Article
Author(s):
Gohlke, H; Ferrari, U; Koczwara, K; Bonifacio, E; Illig, T; Ziegler, AG
Abstract:
It was recently shown that the major allele of the SLC30A8 (zinc transporter 8, ZnT8) single nucleotide polymorphism (SNP) rs13266634 was associated with type 2 diabetes and with reduced insulin secretion in non-diabetic relatives. Because of its role in beta-cell function, we hypothesized that this candidate SNP may confer increased susceptibility for beta-cell destruction in type 1 diabetes. We analyzed SLC30A8 genotypes in 874 patients with type 1 diabetes and 1021 control subjects. No difference in allele and genotype frequencies of the SLC30A8 SNP rs13266634 was found between patients and controls. Analysis with respect to age at type 1 diabetes onset, however, showed that patients with a diabetes onset before age 5 years had an increased prevalence of the cytosine (C) allele (risk allele, 82%) and the homozygous CC genotype (65%) compared to patients who developed type 1 diabetes after age 5 years (67% and 49%; p < 0.01) and compared to controls (69% and 48%; p < 0.03). These data suggest that genetic susceptibility for beta-cell dysfunction in the presence of autoimmunity may lead to accelerated progression and early manifestation of the disease.
Journal title abbreviation:
Rev Diabet Stud
Year:
2008
Journal volume:
5
Journal issue:
1
Pages contribution:
25-7
Language:
eng
Fulltext / DOI:
doi:10.1900/RDS.2008.5.25
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18548167
Print-ISSN:
1613-6071
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
 BibTeX