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Title:

Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Weidinger, S; Baurecht, H; Wagenpfeil, S; Henderson, J; Novak, N; Sandilands, A; Chen, H; Rodriguez, E; O'Regan, GM; Watson, R; Liao, H; Zhao, Y; Barker, JN; Allen, M; Reynolds, N; Meggitt, S; Northstone, K; Smith, GD; Strobl, C; Stahl, C; Kneib, T; Klopp, N; Bieber, T; Behrendt, H; Palmer, CN; Wichmann, HE; Ring, J; Illig, T; McLean, WH; Irvine, AD
Abstract:
BACKGROUND: Polymorphisms in the serine protease inhibitor gene serine peptidase inhibitor Kazal type 5 (SPINK5) and the serine protease kallikrein-related peptidase 7 gene (KLK7) appear to confer risk to eczema in some cohorts, but these findings have not been widely replicated. These genes encode proteins thought to be involved in the regulation of posttranslation processing of filaggrin (FLG), the strongest identified genetic risk factor for eczema to date. OBJECTIVES: We sought to clarify th...     »
Journal title abbreviation:
J Allergy Clin Immunol
Year:
2008
Journal volume:
122
Journal issue:
3
Pages contribution:
560-8.e4
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jaci.2008.05.050
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18774391
Print-ISSN:
0091-6749
TUM Institution:
Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Dermatologie und Allergologie
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