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Title:

Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel.

Document type:
Journal Article; Article
Author(s):
Novak, N; Baurecht, H; Schäfer, T; Rodriguez, E; Wagenpfeil, S; Klopp, N; Heinrich, J; Behrendt, H; Ring, J; Wichmann, E; Illig, T; Weidinger, S
Abstract:
Allergic contact dermatitis is one of the most frequent dermatological problems affecting 7% of the general population. Impaired skin barrier function facilitates the penetration of contact allergens and irritants into the epidermal layer and is regarded as an important cofactor promoting the process of allergic contact sensitization. Filaggrin is crucial for the maintenance of the skin barrier function. Loss-of-function mutations within the filaggrin (FLG) gene are associated with skin barrier...     »
Journal title abbreviation:
J Invest Dermatol
Year:
2008
Journal volume:
128
Journal issue:
6
Pages contribution:
1430-5
Language:
eng
Fulltext / DOI:
doi:10.1038/sj.jid.5701190
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18049447
Print-ISSN:
0022-202X
TUM Institution:
Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Dermatologie und Allergologie
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