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Title:

Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Weidinger, S; Gieger, C; Rodriguez, E; Baurecht, H; Mempel, M; Klopp, N; Gohlke, H; Wagenpfeil, S; Ollert, M; Ring, J; Behrendt, H; Heinrich, J; Novak, N; Bieber, T; Kramer, U; Berdel, D; von Berg, A; Bauer, CP; Herbarth, O; Koletzko, S; Prokisch, H; Mehta, D; Meitinger, T; Depner, M; von Mutius, E; Liang, L; Moffatt, M; Cookson, W; Kabesch, M; Wichmann, HE; Illig, T
Abstract:
High levels of serum IgE are considered markers of parasite and helminth exposure. In addition, they are associated with allergic disorders, play a key role in anti-tumoral defence, and are crucial mediators of autoimmune diseases. Total IgE is a strongly heritable trait. In a genome-wide association study (GWAS), we tested 353,569 SNPs for association with serum IgE levels in 1,530 individuals from the population-based KORA S3/F3 study. Replication was performed in four independent population-b...     »
Journal title abbreviation:
PLoS Genet
Year:
2008
Journal volume:
4
Journal issue:
8
Pages contribution:
e1000166
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pgen.1000166
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18846228
Print-ISSN:
1553-7390
TUM Institution:
Institut für Humangenetik; Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Dermatologie und Allergologie; Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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