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Title:

Filaggrin mutations, atopic eczema, hay fever, and asthma in children.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Weidinger, S; O'Sullivan, M; Illig, T; Baurecht, H; Depner, M; Rodriguez, E; Ruether, A; Klopp, N; Vogelberg, C; Weiland, SK; McLean, WH; von Mutius, E; Irvine, AD; Kabesch, M
Abstract:
BACKGROUND: Mutations in the filaggrin gene (FLG) have been shown to play a significant role in ichthyosis vulgaris and eczema, 2 common chronic skin diseases. However, their role in the development of other atopic diseases such as asthma and rhinitis has not yet been clarified in large population-based studies. OBJECTIVES: To study the effect of FLG mutations at the population level and their effect on other atopic phenotypes. METHODS: Association analysis of the 2 common FLG-null mutations R50...     »
Journal title abbreviation:
J Allergy Clin Immunol
Year:
2008
Journal volume:
121
Journal issue:
5
Pages contribution:
1203-1209.e1
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jaci.2008.02.014
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18396323
Print-ISSN:
0091-6749
TUM Institution:
Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Dermatologie und Allergologie
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