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Titel:

Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel.

Dokumenttyp:
Journal Article; Article
Autor(en):
Novak, N; Baurecht, H; Schäfer, T; Rodriguez, E; Wagenpfeil, S; Klopp, N; Heinrich, J; Behrendt, H; Ring, J; Wichmann, E; Illig, T; Weidinger, S
Abstract:
Allergic contact dermatitis is one of the most frequent dermatological problems affecting 7% of the general population. Impaired skin barrier function facilitates the penetration of contact allergens and irritants into the epidermal layer and is regarded as an important cofactor promoting the process of allergic contact sensitization. Filaggrin is crucial for the maintenance of the skin barrier function. Loss-of-function mutations within the filaggrin (FLG) gene are associated with skin barrier...     »
Zeitschriftentitel:
J Invest Dermatol
Jahr:
2008
Band / Volume:
128
Heft / Issue:
6
Seitenangaben Beitrag:
1430-5
Sprache:
eng
Volltext / DOI:
doi:10.1038/sj.jid.5701190
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18049447
Print-ISSN:
0022-202X
TUM Einrichtung:
Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Dermatologie und Allergologie
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