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Titel:

Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Autor(en):
Junt, T; Moseman, EA; Iannacone, M; Massberg, S; Lang, PA; Boes, M; Fink, K; Henrickson, SE; Shayakhmetov, DM; Di Paolo, NC; van Rooijen, N; Mempel, TR; Whelan, SP; von Andrian, UH
Abstract:
Lymph nodes prevent the systemic dissemination of pathogens such as viruses that infect peripheral tissues after penetrating the body's surface barriers. They are also the staging ground of adaptive immune responses to pathogen-derived antigens. It is unclear how virus particles are cleared from afferent lymph and presented to cognate B cells to induce antibody responses. Here we identify a population of CD11b+CD169+MHCII+ macrophages on the floor of the subcapsular sinus (SCS) and in the medull...     »
Zeitschriftentitel:
Nature
Jahr:
2007
Band / Volume:
450
Heft / Issue:
7166
Seitenangaben Beitrag:
110-4
Sprache:
eng
Volltext / DOI:
doi:10.1038/nature06287
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17934446
Print-ISSN:
0028-0836
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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