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Title:

Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Bevan, S; Dichgans, M; Wiechmann, HE; Gschwendtner, A; Meitinger, T; Markus, HS
Abstract:
BACKGROUND AND PURPOSE: The recent finding that genetic variants in 5-lipoxygenase activating protein and leukotriene A4 hydrolase may confer an increased risk of ischemic stroke has implicated the leukotriene family as potential mediators of cardiovascular disease. Using a case control replication methodology, all members of the leukotriene synthesis pathway and their receptors were examined for genetic variants, which may act as risk factors for all ischemic stroke and stroke subtypes. METHODS...     »
Journal title abbreviation:
Stroke
Year:
2008
Journal volume:
39
Journal issue:
4
Pages contribution:
1109-14
Language:
eng
Fulltext / DOI:
doi:10.1161/STROKEAHA.107.491969
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18323512
Print-ISSN:
0039-2499
TUM Institution:
Institut für Humangenetik
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