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Titel:

Common variants near MC4R are associated with fat mass, weight and risk of obesity.

Dokumenttyp:
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Autor(en):
Loos, RJ; Lindgren, CM; Li, S; Wheeler, E; Zhao, JH; Prokopenko, I; Inouye, M; Freathy, RM; Attwood, AP; Beckmann, JS; Berndt, SI; Jacobs, KB; Chanock, SJ; Hayes, RB; Bergmann, S; Bennett, AJ; Bingham, SA; Bochud, M; Brown, M; Cauchi, S; Connell, JM; Cooper, C; Smith, GD; Day, I; Dina, C; De, S; Dermitzakis, ET; Doney, AS; Elliott, KS; Elliott, P; Evans, DM; Sadaf Farooqi, I; Froguel, P; Ghori, J; Groves, CJ; Gwilliam, R; Hadley, D; Hall, AS; Hattersley, AT; Hebebrand, J; Heid, IM; Lamina, C; Gi...     »
Abstract:
To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2.9 x 10(-6)) mapped 188 kb downstream of MC4R (melanocortin-4 receptor), mutations of which are the leading cause of monogenic severe childhood-onset obesity. We confirmed the BMI association in 60,352 adults (per-allele effect = 0.05 Z-score units; P = 2....     »
Zeitschriftentitel:
Nat Genet
Jahr:
2008
Band / Volume:
40
Heft / Issue:
6
Seitenangaben Beitrag:
768-75
Sprache:
eng
Volltext / DOI:
doi:10.1038/ng.140
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18454148
Print-ISSN:
1061-4036
TUM Einrichtung:
Institut für Humangenetik
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