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Title:

Overexpression of LASP-1 mediates migration and proliferation of human ovarian cancer cells and influences zyxin localisation.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Grunewald, TG; Kämmerer, U; Winkler, C; Schindler, D; Sickmann, A; Honig, A; Butt, E
Abstract:
LIM and SH3 protein 1 (LASP-1), initially identified from human breast cancer, is a specific focal adhesion protein involved in cell proliferation and migration. In the present work, we analysed the effect of LASP-1 on biology and function of human ovarian cancer cell line SKOV-3 using small interfering RNA technique (siRNA).Transfection with LASP-1-specific siRNA resulted in a reduced protein level of LASP-1 in SKOV-3 cells. The siRNA-treated cells were arrested in G(2)/M phase of the cell cycl...     »
Journal title abbreviation:
Br J Cancer
Year:
2007
Journal volume:
96
Journal issue:
2
Pages contribution:
296-305
Language:
eng
Fulltext / DOI:
doi:10.1038/sj.bjc.6603545
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17211471
Print-ISSN:
0007-0920
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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