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Title:

No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Müller, TD; Reichwald, K; Wermter, AK; Brönner, G; Nguyen, TT; Friedel, S; Koberwitz, K; Engeli, S; Lichtner, P; Meitinger, T; Schäfer, H; Hebebrand, J; Hinney, A
Abstract:
Studies in rodent models demonstrated that the central cannabinoid receptor (Cnr1) mediates the orexigenic effects of cannabinoids. To analyze whether genetic variation in the cannabinoid receptor gene (CNR1) is implicated in human obesity, we initially genotyped 8 single nucleotide polymorphisms (SNPs) located in the 5' region (rs9353527, rs754387, rs6454676), intron 2 (rs806379, rs1535255), exon 3 (rs2023239), intron 3 (rs806370) and the coding region (rs1049353) in up to 364 German obesity tr...     »
Journal title abbreviation:
Mol Genet Metab
Year:
2007
Journal volume:
90
Journal issue:
4
Pages contribution:
429-34
Language:
eng
Fulltext / DOI:
doi:10.1016/j.ymgme.2007.01.002
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17292652
Print-ISSN:
1096-7192
TUM Institution:
Institut für Humangenetik
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