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Titel:

No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Müller, TD; Reichwald, K; Wermter, AK; Brönner, G; Nguyen, TT; Friedel, S; Koberwitz, K; Engeli, S; Lichtner, P; Meitinger, T; Schäfer, H; Hebebrand, J; Hinney, A
Abstract:
Studies in rodent models demonstrated that the central cannabinoid receptor (Cnr1) mediates the orexigenic effects of cannabinoids. To analyze whether genetic variation in the cannabinoid receptor gene (CNR1) is implicated in human obesity, we initially genotyped 8 single nucleotide polymorphisms (SNPs) located in the 5' region (rs9353527, rs754387, rs6454676), intron 2 (rs806379, rs1535255), exon 3 (rs2023239), intron 3 (rs806370) and the coding region (rs1049353) in up to 364 German obesity tr...     »
Zeitschriftentitel:
Mol Genet Metab
Jahr:
2007
Band / Volume:
90
Heft / Issue:
4
Seitenangaben Beitrag:
429-34
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.ymgme.2007.01.002
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17292652
Print-ISSN:
1096-7192
TUM Einrichtung:
Institut für Humangenetik
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