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Title:

Effect of oral organic nitrates on expression and activity of vascular soluble guanylyl cyclase.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Oppermann, M; Dao, VT; Suvorava, T; Bas, M; Kojda, G
Abstract:
BACKGROUND AND PURPOSE: The regulation of vascular soluble guanylyl cyclase (sGC) expression by nitric oxide (NO) is still under discussion. In vitro, NO has been shown to downregulate the expression of sGC but it is unclear if this mechanism is operative in vivo and occurs during nitrate treatment. EXPERIMENTAL APPROACH: We investigated whether high dose isosorbide mononitrate (ISMN) or pentaerythrityl tetranitrate (PETN) treatment changes vascular sGC expression and activity in vivo. New Zeala...     »
Journal title abbreviation:
Br J Pharmacol
Year:
2008
Journal volume:
155
Journal issue:
3
Pages contribution:
335-42
Language:
eng
Fulltext / DOI:
doi:10.1038/bjp.2008.269
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18587420
Print-ISSN:
0007-1188
TUM Institution:
Hals-Nasen-Ohrenklinik und Poliklinik
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