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Title:

Immunological characterization of missense mutations occurring within cytotoxic T cell-defined p53 epitopes in HLA-A*0201+ squamous cell carcinomas of the head and neck.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Ito, D; Visus, C; Hoffmann, TK; Balz, V; Bier, H; Appella, E; Whiteside, TL; Ferris, RL; DeLeo, AB
Abstract:
Previous analyses of p53 in 40 HLA-A*0201(HLA-A2)(+) squamous cell carcinomas of the head and neck (SCCHN) indicated that 6/13 p53 missense mutations that were detected, S149C, T150R, V157F, Y220C, Y220H and E271K, occurred within HLA-A2-restricted cytotoxic T lymphocyte (CTL)-defined p53 epitopes. Of the 6, the p53 S149C, Y220C and Y220H peptides were immunogenic. Anti-p53 mutant S149C and Y220H effector cells cross-reacted against the parental wild type sequence (wt) p53 peptides, whereas anti...     »
Journal title abbreviation:
Int J Cancer
Year:
2007
Journal volume:
120
Journal issue:
12
Pages contribution:
2618-24
Language:
eng
Fulltext / DOI:
doi:10.1002/ijc.22584
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17294448
Print-ISSN:
0020-7136
TUM Institution:
Hals-Nasen-Ohrenklinik und Poliklinik
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