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Title:

The hypoxia-inducible factor HIF-1 promotes intramyocardial expression of VEGF in infants with congenital cardiac defects.

Document type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Qing, M; Quing, M; Gorlach, A; Schumacher, K; Wöltje, M; Vazquez-Jimenez, JF; Hess, J; Seghaye, MC
Abstract:
OBJECTIVES : The response to hypoxia is primarily mediated by the transcription factor hypoxia-inducible factor-1 (HIF-1) which leads to the induction of a variety of adaptive gene products including vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS). This study was designed to test the hypothesis that HIF-1 and its target genes would be upregulated in the ventricular myocardium of infants with cyanotic congenital cardiac defects. METHODS : 14 infants with cya...     »
Journal title abbreviation:
Basic Res Cardiol
Year:
2007
Journal volume:
102
Journal issue:
3
Pages contribution:
224-32
Language:
eng
Fulltext / DOI:
doi:10.1007/s00395-007-0639-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17268888
Print-ISSN:
0300-8428
TUM Institution:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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