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Titel:

Deficiency of manganese superoxide dismutase in hepatocytes disrupts zonated gene expression in mouse liver.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Lenart, J; Dombrowski, F; Gorlach, A; Kietzmann, T
Abstract:
The liver acinus displays a physiological periportal to perivenous oxygen gradient. This gradient was implicated to use reactive oxygen species (ROS) as mediators for the zonal gene expression. Mitochondria use oxygen and produce ROS, therefore they may contribute to the zonation of gene expression. To further elucidate this, we used the Cre-loxP system to generate a hepatocyte-specific null mutation of the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) in mice. We found...     »
Zeitschriftentitel:
Arch Biochem Biophys
Jahr:
2007
Band / Volume:
462
Heft / Issue:
2
Seitenangaben Beitrag:
238-44
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.abb.2007.02.007
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17367743
Print-ISSN:
0003-9861
TUM Einrichtung:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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