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Title:

Superoxide and derived reactive oxygen species in the regulation of hypoxia-inducible factors.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Gorlach, A; Kietzmann, T
Abstract:
Superoxide and its derived reactive oxygen species (ROS) have been considered for a long time to be generated as toxic byproducts of metabolic events. More recently, it has been acknowledged that ROS generated in low amounts are also able to act as signaling molecules in a variety of responses. One of the major pathways regulated by the ambient concentration of oxygen relies on the activity of hypoxia-inducible transcription factors (HIF). Originally described to be only induced and activated un...     »
Journal title abbreviation:
Methods Enzymol
Year:
2007
Journal volume:
435
Pages contribution:
421-46
Language:
eng
Fulltext / DOI:
doi:10.1016/S0076-6879(07)35022-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17998067
Print-ISSN:
0076-6879
TUM Institution:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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