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Title:

Biology of Isl1+ cardiac progenitor cells in development and disease.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review; Review
Author(s):
Moretti, A; Lam, J; Evans, SM; Laugwitz, KL
Abstract:
The LIM-homeodomain transcription factor Islet-1 (Isl1) marks a cell population which makes a substantial contribution to the embryonic heart. Isl1 expression is downregulated as soon as the cells adopt a differentiated phenotype, suggesting that this transcription factor delineates a cardiogenic progenitor cell population. Taking advantage of this developmental lineage marker, we have identified in the postnatal heart a novel cardiac cell type, which is capable of self-renewal and readily diffe...     »
Journal title abbreviation:
Cell Mol Life Sci
Year:
2007
Journal volume:
64
Journal issue:
6
Pages contribution:
674-82
Language:
eng
Fulltext / DOI:
doi:10.1007/s00018-007-6520-5
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17380308
Print-ISSN:
1420-682X
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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