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Title:

Extracellular matrix metalloproteinase inducer (CD147) is a novel receptor on platelets, activates platelets, and augments nuclear factor kappaB-dependent inflammation in monocytes.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Schmidt, R; Bültmann, A; Fischel, S; Gillitzer, A; Cullen, P; Walch, A; Jost, P; Ungerer, M; Tolley, ND; Lindemann, S; Gawaz, M; Schömig, A; May, AE
Abstract:
In atherosclerosis, circulating platelets interact with endothelial cells and monocytes, leading to cell activation and enhanced recruitment of leukocytes into the vascular wall. The invasion of monocytes is accompanied by overexpression of matrix metalloproteinases (MMPs), which are thought to promote atherosclerosis and trigger plaque rupture. Following interaction with itself, the extracellular matrix metalloproteinase inducer (EMMPRIN) induces MMP synthesis via a little-known intracellular p...     »
Journal title abbreviation:
Circ Res
Year:
2008
Journal volume:
102
Journal issue:
3
Pages contribution:
302-9
Language:
eng
Fulltext / DOI:
doi:10.1161/CIRCRESAHA.107.157990
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18048771
Print-ISSN:
0009-7330
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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