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Title:

TRADD protein is an essential component of the RIG-like helicase antiviral pathway.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Michallet, MC; Meylan, E; Ermolaeva, MA; Vazquez, J; Rebsamen, M; Curran, J; Poeck, H; Bscheider, M; Hartmann, G; Konig, M; Kalinke, U; Pasparakis, M; Tschopp, J
Abstract:
Upon detection of viral RNA, the helicases RIG-I and/or MDA5 trigger, via their adaptor Cardif (also known as IPS-1, MAVS, or VISA), the activation of the transcription factors NF-kappaB and IRF3, which collaborate to induce an antiviral type I interferon (IFN) response. FADD and RIP1, known as mediators of death-receptor signaling, are implicated in this antiviral pathway; however, the link between death-receptor and antiviral signaling is not known. Here we showed that TRADD, a crucial adapto...     »
Journal title abbreviation:
Immunity
Year:
2008
Journal volume:
28
Journal issue:
5
Pages contribution:
651-61
Language:
eng
Fulltext / DOI:
doi:10.1016/j.immuni.2008.03.013
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18439848
Print-ISSN:
1074-7613
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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