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Titel:

Cetuximab in combination with weekly 5-fluorouracil/folinic acid and oxaliplatin (FUFOX) in untreated patients with advanced colorectal cancer: a phase Ib/II study of the AIO GI Group.

Dokumenttyp:
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Multicenter Study
Autor(en):
Arnold, D; Höhler, T; Dittrich, C; Lordick, F; Seufferlein, T; Riemann, J; Wöll, E; Herrmann, T; Zubel, A; Schmoll, HJ
Abstract:
BACKGROUND: This two-part phase Ib/II study investigated the feasibility of administering cetuximab in combination with oxaliplatin and infusional 5-fluorouracil (5-FU)/folinic acid (FA) in a weekly schedule (AIO FUFOX protocol) as first-line treatment in patients with epidermal growth factor receptor-detectable advanced colorectal cancer. PATIENTS AND METHODS: Cetuximab was administered weekly: 400 mg/m(2) initial dose, then 250 mg/m(2) and FUFOX: oxaliplatin 50 mg/m(2), FA 500 mg/m(2) and 5-FU...     »
Zeitschriftentitel:
Ann Oncol
Jahr:
2008
Band / Volume:
19
Heft / Issue:
8
Seitenangaben Beitrag:
1442-9
Sprache:
eng
Volltext / DOI:
doi:10.1093/annonc/mdn150
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18441330
Print-ISSN:
0923-7534
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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