Benutzer: Gast  Login
Titel:

Neoadjuvant gene delivery of feline granulocyte-macrophage colony-stimulating factor using magnetofection for the treatment of feline fibrosarcomas: a phase I trial.

Dokumenttyp:
Journal Article
Autor(en):
Hüttinger, C; Hirschberger, J; Jahnke, A; Köstlin, R; Brill, T; Plank, C; Küchenhoff, H; Krieger, S; Schillinger, U
Abstract:
Despite aggressive pre- or postoperative treatment, feline fibrosarcomas have high recurrence rates. Immunostimulatory gene therapy is a promising approach in veterinary oncology. This phase I dose-escalation study was performed to determine toxicity and feasibility of gene therapy with feline granulocyte-macrophage colony-stimulating factor (feGM-CSF) in cats with fibrosarcomas. Twenty cats were treated with plasmid coding for feGM-CSF attached to magnetic nanoparticles in doses of 50, 250, 750...     »
Zeitschriftentitel:
J Gene Med
Jahr:
2008
Band / Volume:
10
Heft / Issue:
6
Seitenangaben Beitrag:
655-67
Sprache:
eng
Volltext / DOI:
doi:10.1002/jgm.1185
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18338834
Print-ISSN:
1099-498X
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
 BibTeX