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Title:

In vitro metabolism of 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid (licofelone, ML3000), an inhibitor of cyclooxygenase-1 and -2 and 5-lipoxygenase.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Albrecht, W; Unger, A; Nüssler, AK; Laufer, S
Abstract:
2-[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid (licofelone) is a dual inhibitor of both cyclooxygenase isoforms and 5-lipoxygenase and under development for treatment of osteoarthritis. In conventional in vitro assays using liver microsomes and NADPH as cosubstrate, a high metabolic stability of licofelone was observed. In the presence of UDP-glucuronic acid, licofelone is rapidly converted into the corresponding acyl glucuronide, M1. These results are in...     »
Journal title abbreviation:
Drug Metab Dispos
Year:
2008
Journal volume:
36
Journal issue:
5
Pages contribution:
894-903
Fulltext / DOI:
doi:10.1124/dmd.108.020347
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18268076
Print-ISSN:
0090-9556
TUM Institution:
Klinik und Poliklinik für Unfallchirurgie
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