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Titel:

Blood monocyte-derived neohepatocytes as in vitro test system for drug metabolism.

Dokumenttyp:
In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Ehnert, S; Nüssler, AK; Lehmann, A; Dooley, S
Abstract:
The gold standard for human drug metabolism studies is primary hepatocytes. However, availability is limited by donor organ scarcity. Therefore, efforts have been made to provide alternatives, e.g., the hepatocyte-like (NeoHep) cell type, which was generated from peripheral blood monocytes. In this study, expression and activity of phase I and phase II drug-metabolizing enzymes were investigated during transdifferentiation of NeoHep cells and compared with primary human hepatocytes. Important dr...     »
Zeitschriftentitel:
Drug Metab Dispos
Jahr:
2008
Band / Volume:
36
Heft / Issue:
9
Seitenangaben Beitrag:
1922-9
Volltext / DOI:
doi:10.1124/dmd.108.020453
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18559486
Print-ISSN:
0090-9556
TUM Einrichtung:
Klinik und Poliklinik für Unfallchirurgie
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