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Titel:

Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Autor(en):
Vega, VL; Rodríguez-Silva, M; Frey, T; Gehrmann, M; Diaz, JC; Steinem, C; Multhoff, G; Arispe, N; De Maio, A
Abstract:
Heat shock proteins (hsps) are intracellular chaperones that play a key role in the recovery from stress. Hsp70, the major stress-induced hsp, has been found in the extracellular medium and is capable of activating immune cells. The mechanism involved in Hsp70 release is controversial because this protein does not present a consensual secretory signal. In this study, we have shown that Hsp70 integrates into artificial lipid bilayer openings of ion conductance pathways. In addition, this protein...     »
Zeitschriftentitel:
J Immunol
Jahr:
2008
Band / Volume:
180
Heft / Issue:
6
Seitenangaben Beitrag:
4299-307
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18322243
Print-ISSN:
0022-1767
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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