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Titel:

Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice.

Dokumenttyp:
Journal Article
Autor(en):
Vasiljeva, O; Korovin, M; Gajda, M; Brodoefel, H; Boji?, L; Kruger, A; Schurigt, U; Sevenich, L; Türk, B; Peters, C; Reinheckel, T
Abstract:
Expression levels of the papain-like cysteine protease cathepsin B (Ctsb) have been positively correlated with mammary tumour progression and metastasis; however, its roles in the hallmark processes of malignant growth remain poorly defined. Using Ctsb-deficient mice we investigated tumour cell differentiation, proliferation and apoptosis in the Tg(MMTV-PyMT) mouse mammary cancer model. Absence of Ctsb significantly impaired development of high-grade invasive ductal carcinomas and reduced the m...     »
Zeitschriftentitel:
Oncogene
Jahr:
2008
Band / Volume:
27
Heft / Issue:
30
Seitenangaben Beitrag:
4191-9
Sprache:
eng
Volltext / DOI:
doi:10.1038/onc.2008.59
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18345026
Print-ISSN:
0950-9232
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
Format:
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