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Titel:

Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Zhong, JL; Poghosyan, Z; Pennington, CJ; Scott, X; Handsley, MM; Warn, A; Gavrilovic, J; Honert, K; Kruger, A; Span, PN; Sweep, FC; Edwards, DR
Abstract:
Adamalysins [a disintegrin and metalloproteinase (ADAM)] are a family of cell surface transmembrane proteins that have broad biological functions encompassing proteolysis, adhesion, and cell signal regulation. We previously showed that the cytoplasmic domain of ADAM-15 interacts with Src family protein tyrosine kinases and the adaptor protein growth factor receptor binding protein 2 (Grb2). In the present study, we have cloned and characterized four alternatively spliced forms of ADAM-15, which...     »
Zeitschriftentitel:
Mol Cancer Res
Jahr:
2008
Band / Volume:
6
Heft / Issue:
3
Seitenangaben Beitrag:
383-94
Sprache:
eng
Volltext / DOI:
doi:10.1158/1541-7786.MCR-07-2028
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18296648
Print-ISSN:
1541-7786
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
Format:
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