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Title:

Impact of radiation therapy on the oncolytic adenovirus dl520: Implications on the treatment of glioblastoma.

Document type:
Journal Article
Author(s):
Bieler, A; Mantwill, K; Holzmüller, R; Jürchott, K; Kaszubiak, A; Stark, S; Glockzin, G; Lage, H; Grosu, AL; Gansbacher, B; Holm, PS
Abstract:
BACKGROUND AND PURPOSE: Viral oncolytic therapy is emerging as a new form of anticancer therapy and has shown promising preclinical results, especially in combination with radio- and chemotherapy. We recently reported that nuclear localization of the human transcription factor YB-1 in multidrug-resistant cells facilitates E1-independent adenoviral replication. The aim of this study was to evaluate the combined treatment of the conditionally-replicating adenovirus dl520 and radiotherapy in glioma...     »
Journal title abbreviation:
Radiother Oncol
Year:
2008
Journal volume:
86
Journal issue:
3
Pages contribution:
419-27
Language:
eng
Fulltext / DOI:
doi:10.1016/j.radonc.2007.10.009
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17967494
Print-ISSN:
0167-8140
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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