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Title:

Relevance of endotoxin receptor CD14 and TLR4 gene variants in chronic liver disease.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
von Hahn, T; Halangk, J; Witt, H; Neumann, K; Müller, T; Puhl, G; Neuhaus, P; Nickel, R; Beuers, U; Wiedenmann, B; Berg, T
Abstract:
OBJECTIVE: The lipopolysaccharide (LPS)-triggered release of inflammatory cytokines from Kupffer cells is mediated via the CD14/TLR4 receptor complex. This inflammatory pathway can be influenced by alterations in genes encoding for LPS receptor components. Thus, a -260 C>T transition in the CD14 promoter is thought to result in enhanced CD14 expression thereby increasing the LPS responsiveness in chronic liver diseases, whereas a D299G exchange in the TLR4 gene has the opposite effect. Our objec...     »
Journal title abbreviation:
Scand J Gastroenterol
Year:
2008
Journal volume:
43
Journal issue:
5
Pages contribution:
584-92
Language:
eng
Fulltext / DOI:
doi:10.1080/00365520701806065
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18415752
Print-ISSN:
0036-5521
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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