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Title:

The HMG-CoA reductase inhibitor rosuvastatin inhibits plasminogen activator inhibitor-1 expression and secretion in human adipocytes.

Document type:
Journal Article; Article
Author(s):
Laumen, H; Skurk, T; Hauner, H
Abstract:
Human preadipocytes and adipocytes are known to produce the proatherogenic factor PAI-1 and proinflammatory cytokines, and obesity was found to be state of increased adipose production of these factors. In the present study, we investigated the effect of rosuvastatin on the regulation of PAI-1 gene expression in human adipocytes. Human preadipocytes, adipocytes in primary culture and the SGBS cell line were used as cell models. Cells were transfected using various constructs and promoter activit...     »
Journal title abbreviation:
Atherosclerosis
Year:
2008
Journal volume:
196
Journal issue:
2
Pages contribution:
565-73
Language:
eng
Fulltext / DOI:
doi:10.1016/j.atherosclerosis.2007.06.005
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17692320
Print-ISSN:
0021-9150
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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