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Title:

T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Kintscher, U; Hartge, M; Hess, K; Foryst-Ludwig, A; Clemenz, M; Wabitsch, M; Fischer-Posovszky, P; Barth, TF; Dragun, D; Skurk, T; Hauner, H; Blüher, M; Unger, T; Wolf, AM; Knippschild, U; Hombach, V; Marx, N
Abstract:
BACKGROUND: Adipose tissue inflammation may play a critical role in the pathogenesis of insulin resistance (IR). The present study examined the role of lymphocytes in adipose tissue inflammation and IR. METHODS AND RESULTS: In a mouse model of obesity-mediated IR, high-fat diet (HFD) induced IR already after 5 weeks, which was associated with a marked T-lymphocyte infiltration in visceral adipose tissue. In contrast, recruitment of macrophages was delayed with an increase of MAC3-positive staini...     »
Journal title abbreviation:
Arterioscler Thromb Vasc Biol
Year:
2008
Journal volume:
28
Journal issue:
7
Pages contribution:
1304-10
Language:
eng
Fulltext / DOI:
doi:10.1161/ATVBAHA.108.165100
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18420999
Print-ISSN:
1079-5642
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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