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Title:

Heterogeneous metastasis efficiency of isogenic orthotopic colon cancer xenografts reveals distinctive gene expression profiles.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Abal, M; Fsihi, H; Bras-Gonçalves, R; Doll, A; Boyé, K; Janssen, KP; Alameda, F; Reventós, J; Louvard, D; Magdelenat, H; Poupon, MF; Robine, S
Abstract:
Hepatic and lung metastases are the leading causes of mortality and major indicators of aggressiveness in colorectal cancer. The underlying molecular mechanisms contributing to the development of metastasis are still unclear. Here, we designed a novel approach to explore gene expression profiles associated with metastasis in human colorectal cancer (hCRC). A series of ten isogenic tumors from three different hCRC models were orthotopically implanted into nude mice. In these series, we analyzed t...     »
Journal title abbreviation:
Tumour Biol
Year:
2007
Journal volume:
28
Journal issue:
3
Pages contribution:
139-50
Language:
eng
Fulltext / DOI:
doi:10.1159/000103009
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17519533
Print-ISSN:
1010-4283
TUM Institution:
Chirurgische Klinik und Poliklinik
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