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Title:

Ozonized low density lipoprotein (ozLDL) inhibits NF-kappaB and IRAK-1-associated signaling.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Cappello, C; Saugel, B; Huth, KC; Zwergal, A; Krautkrämer, M; Furman, C; Rouis, M; Wieser, B; Schneider, HW; Neumeier, D; Brand, K
Abstract:
OBJECTIVE: Recent studies have provided strong evidence for the presence of ozone in atherosclerotic lesions. In addition, modification of LDL has been suggested to be involved in atherosclerosis. In the present study we wanted to investigate whether LDL exposed to ozone (ozLDL) is able to modulate the NF-kappaB system, as a paradigm for inflammatory signaling. METHODS AND RESULTS: We showed that activation of NF-kappaB by lipopolysaccharide (LPS), a prototypic inducer of innate immunity, was re...     »
Journal title abbreviation:
Arterioscler Thromb Vasc Biol
Year:
2007
Journal volume:
27
Journal issue:
1
Pages contribution:
226-32
Language:
eng
Fulltext / DOI:
doi:10.1161/01.ATV.0000250615.27795.85
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17053167
Print-ISSN:
1079-5642
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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