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Titel:

Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Kopitz, C; Gerg, M; Bandapalli, OR; Ister, D; Pennington, CJ; Hauser, S; Flechsig, C; Krell, HW; Antolovic, D; Brew, K; Nagase, H; Stangl, M; von Weyhern, CW; Brücher, BL; Brand, K; Coussens, LM; Edwards, DR; Kruger, A
Abstract:
Balanced expression of proteases and their inhibitors is one prerequisite of tissue homeostasis. Metastatic spread of tumor cells through the organism depends on proteolytic activity and is the death determinant for cancer patients. Paradoxically, increased expression of tissue inhibitor of metalloproteinases-1 (TIMP-1), a natural inhibitor of several endometalloproteinases, including matrix metalloproteinases and a disintegrin and metalloproteinase-10 (ADAM-10), in cancer patients is negatively...     »
Zeitschriftentitel:
Cancer Res
Jahr:
2007
Band / Volume:
67
Heft / Issue:
18
Seitenangaben Beitrag:
8615-23
Sprache:
eng
Volltext / DOI:
doi:10.1158/0008-5472.CAN-07-0232
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17875701
Print-ISSN:
0008-5472
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Experimentelle Onkologie und Therapieforschung; Institut für Klinische Chemie und Pathobiochemie
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