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Title:

Application of 188rhenium as an alternative radionuclide for treatment of prostate cancer after tumor-specific sodium iodide symporter gene expression.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Author(s):
Willhauck, MJ; Sharif Samani, BR; Gildehaus, FJ; Wolf, I; Senekowitsch-Schmidtke, R; Stark, HJ; Göke, B; Morris, JC; Spitzweg, C
Abstract:
CONTEXT: We reported recently the induction of iodide accumulation in prostate cancer cells (LNCaP) by prostate-specific antigen promoter-directed sodium iodide symporter (NIS) expression that allowed a significant therapeutic effect of (131)iodine ((131)I). These data demonstrated the potential of the NIS gene as a novel therapeutic gene, although in some extrathyroidal tumors, therapeutic efficacy may be limited by rapid iodide efflux due to a lack of iodide organification. OBJECTIVE: In the c...     »
Journal title abbreviation:
J Clin Endocrinol Metab
Year:
2007
Journal volume:
92
Journal issue:
11
Pages contribution:
4451-8
Language:
eng
Fulltext / DOI:
doi:10.1210/jc.2007-0402
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17698909
Print-ISSN:
0021-972X
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
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