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Title:

Bortezomib in combination with dexamethasone for patients with relapsed Hodgkin's lymphoma: results of a prematurely closed phase II study (NCT00148018).

Document type:
Clinical Trial, Phase II; Comparative Study; Letter; Multicenter Study; Research Support, Non-U.S. Gov't; Letter
Author(s):
Trelle, S; Sezer, O; Naumann, R; Rummel, M; Keller, U; Engert, A; Borchmann, P
Abstract:
We conducted a two-stage phase II study to investigate the activity of bortezomib and dexamethasone in patients with relapsed Hodgkin's lymphoma. The study was prematurely closed after the first stage with twelve enrolled patients because no response was observed. A meta-analysis of all four available studies evaluating bortezomib in this population showed no activity of bortezomib (combined response rate: 0.03; 95%-CI: 0.01 to 0.12).
Journal title abbreviation:
Haematologica
Year:
2007
Journal volume:
92
Journal issue:
4
Pages contribution:
568-9
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17488673
Print-ISSN:
0390-6078
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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