Bortezomib in combination with dexamethasone for patients with relapsed Hodgkin's lymphoma: results of a prematurely closed phase II study (NCT00148018).

Titel:: Bortezomib in combination with dexamethasone for patients with relapsed Hodgkin's lymphoma: results of a prematurely closed phase II study (NCT00148018).
Dokumenttyp:: Clinical Trial, Phase II; Comparative Study; Letter; Multicenter Study; Research Support, Non-U.S. Gov't; Letter
Autor(en):: Trelle, S; Sezer, O; Naumann, R; Rummel, M; Keller, U; Engert, A; Borchmann, P
Abstract:: We conducted a two-stage phase II study to investigate the activity of bortezomib and dexamethasone in patients with relapsed Hodgkin's lymphoma. The study was prematurely closed after the first stage with twelve enrolled patients because no response was observed. A meta-analysis of all four available studies evaluating bortezomib in this population showed no activity of bortezomib (combined response rate: 0.03; 95%-CI: 0.01 to 0.12).
Zeitschriftentitel:: Haematologica
Jahr:: 2007
Band / Volume:: 92
Heft / Issue:: 4
Seitenangaben Beitrag:: 568-9
Sprache:: eng
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/17488673
Print-ISSN:: 0390-6078
TUM Einrichtung:: III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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